UniProt functional annotation for P39935



	UniProt functional annotation for P39935

UniProt code: P39935.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4631 is probably essential when TIF4632 is missing. {ECO:0000269|PubMed:10357826, ECO:0000269|PubMed:9256432}.

Subunit: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with PAT1 in a RNA-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10357826, ECO:0000269|PubMed:10944120, ECO:0000269|PubMed:11741542, ECO:0000269|PubMed:9256432, ECO:0000269|PubMed:9702200}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.

Miscellaneous: Present with 9760 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the eukaryotic initiation factor 4G family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4631 is probably essential when TIF4632 is missing. {ECO:0000269\|PubMed:10357826, ECO:0000269\|PubMed:9256432}.


Subunit:		Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A (TIF1/TIF2), eIF4E (TIF45) and eIF4G (TIF4631 or TIF4632) (By similarity). Interacts with PAT1 in a RNA-dependent manner. {ECO:0000250, ECO:0000269\|PubMed:10357826, ECO:0000269\|PubMed:10944120, ECO:0000269\|PubMed:11741542, ECO:0000269\|PubMed:9256432, ECO:0000269\|PubMed:9702200}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:14562095}.
Miscellaneous:		Present with 9760 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the eukaryotic initiation factor 4G family. {ECO:0000305}.