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UniProt functional annotation for Q9I840 | ||
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| UniProt code: Q9I840. |
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| Organism: | |
Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Calloselasma. |
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| Function: | |
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. {ECO:0000269|PubMed:11287424, ECO:0000269|PubMed:11352922, ECO:0000269|PubMed:11453648, ECO:0000269|PubMed:11728470, ECO:0000269|PubMed:14630793, ECO:0000269|PubMed:16174766, ECO:0000269|PubMed:7639679, ECO:0000269|PubMed:9588185}. |
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| Subunit: | |
Dimer (non-covalently linked) of heterodimers of subunits alpha and beta (disulfide-linked). {ECO:0000269|PubMed:11728470, ECO:0000269|PubMed:18583525, ECO:0000269|PubMed:18597489, ECO:0000269|PubMed:9588185}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.