UniProt functional annotation for P0DOE7



	UniProt functional annotation for P0DOE7

UniProt code: P0DOE7.

Organism: Human respiratory syncytial virus A (strain A2).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.

Function: Plays a crucial role in virus assembly into filaments and budding (PubMed:25673702, PubMed:27654298, PubMed:23903836, PubMed:24672034). Early in infection, localizes in the nucleus where it may inhibit host cell transcription (PubMed:12827470). Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication (PubMed:19297465, PubMed:23903836). During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer (PubMed:11907323, PubMed:12350355, PubMed:15958665, PubMed:18579594). {ECO:0000269|PubMed:11907323, ECO:0000269|PubMed:12350355, ECO:0000269|PubMed:12827470, ECO:0000269|PubMed:15958665, ECO:0000269|PubMed:18579594, ECO:0000269|PubMed:19297465, ECO:0000269|PubMed:23903836, ECO:0000269|PubMed:24672034, ECO:0000269|PubMed:25673702, ECO:0000269|PubMed:27654298}.

Subunit: Forms dimers (PubMed:29510513, PubMed:25673702). Forms higher- order oligomers (PubMed:24672034). Interacts with glycoprotein G (via N-terminus) (PubMed:15958665). Interacts with protein M2-1; this interaction directs the matrix protein localization to cytoplasmic inclusions comprising viral proteins L, N, P, and M2-1 and mediates the matrix protein association with the nucleocapsid (PubMed:18579594). Interacts with host importin KPNB1; this interaction mediates nuclear import of the matrix protein early during infection (PubMed:16171404). Interacts with host AP3M1; this interaction plays an essential role in trafficking the matrix protein in host cells (PubMed:29028839). Interacts with host CAV1; this interaction probably facilitates viral budding (PubMed:25556234). Interacts with host CFL1; this interaction probably facilitates viral replication (PubMed:25556234). Interacts with host ZNF502; this interaction probably facilitates viral release (PubMed:25556234). {ECO:0000269|PubMed:15958665, ECO:0000269|PubMed:16171404, ECO:0000269|PubMed:18579594, ECO:0000269|PubMed:24672034, ECO:0000269|PubMed:25556234, ECO:0000269|PubMed:25673702, ECO:0000269|PubMed:29028839, ECO:0000269|PubMed:29510513}.

Subcellular location: Virion {ECO:0000269|PubMed:24672034}. Host cytoplasm {ECO:0000269|PubMed:15958665, ECO:0000269|PubMed:19297465, ECO:0000269|PubMed:24672034, ECO:0000269|PubMed:29028839}. Host nucleus {ECO:0000269|PubMed:12827470, ECO:0000269|PubMed:15958665, ECO:0000269|PubMed:16171404, ECO:0000269|PubMed:19297465}. Host cell membrane {ECO:0000269|PubMed:12350355}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the cytoplasm, associates with inclusion bodies (PubMed:23903836). During bud formation, associates at the inner side of the plasma membrane of infected cells. {ECO:0000269|PubMed:23903836, ECO:0000305}.

Ptm: Phosphorylation is important for oligomerization. {ECO:0000269|PubMed:24672034}.

Similarity: Belongs to the pneumovirinae M protein family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Human respiratory syncytial virus A (strain A2).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.



Function:		Plays a crucial role in virus assembly into filaments and budding (PubMed:25673702, PubMed:27654298, PubMed:23903836, PubMed:24672034). Early in infection, localizes in the nucleus where it may inhibit host cell transcription (PubMed:12827470). Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication (PubMed:19297465, PubMed:23903836). During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer (PubMed:11907323, PubMed:12350355, PubMed:15958665, PubMed:18579594). {ECO:0000269\|PubMed:11907323, ECO:0000269\|PubMed:12350355, ECO:0000269\|PubMed:12827470, ECO:0000269\|PubMed:15958665, ECO:0000269\|PubMed:18579594, ECO:0000269\|PubMed:19297465, ECO:0000269\|PubMed:23903836, ECO:0000269\|PubMed:24672034, ECO:0000269\|PubMed:25673702, ECO:0000269\|PubMed:27654298}.


Subunit:		Forms dimers (PubMed:29510513, PubMed:25673702). Forms higher- order oligomers (PubMed:24672034). Interacts with glycoprotein G (via N-terminus) (PubMed:15958665). Interacts with protein M2-1; this interaction directs the matrix protein localization to cytoplasmic inclusions comprising viral proteins L, N, P, and M2-1 and mediates the matrix protein association with the nucleocapsid (PubMed:18579594). Interacts with host importin KPNB1; this interaction mediates nuclear import of the matrix protein early during infection (PubMed:16171404). Interacts with host AP3M1; this interaction plays an essential role in trafficking the matrix protein in host cells (PubMed:29028839). Interacts with host CAV1; this interaction probably facilitates viral budding (PubMed:25556234). Interacts with host CFL1; this interaction probably facilitates viral replication (PubMed:25556234). Interacts with host ZNF502; this interaction probably facilitates viral release (PubMed:25556234). {ECO:0000269\|PubMed:15958665, ECO:0000269\|PubMed:16171404, ECO:0000269\|PubMed:18579594, ECO:0000269\|PubMed:24672034, ECO:0000269\|PubMed:25556234, ECO:0000269\|PubMed:25673702, ECO:0000269\|PubMed:29028839, ECO:0000269\|PubMed:29510513}.
Subcellular location:		Virion {ECO:0000269\|PubMed:24672034}. Host cytoplasm {ECO:0000269\|PubMed:15958665, ECO:0000269\|PubMed:19297465, ECO:0000269\|PubMed:24672034, ECO:0000269\|PubMed:29028839}. Host nucleus {ECO:0000269\|PubMed:12827470, ECO:0000269\|PubMed:15958665, ECO:0000269\|PubMed:16171404, ECO:0000269\|PubMed:19297465}. Host cell membrane {ECO:0000269\|PubMed:12350355}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the cytoplasm, associates with inclusion bodies (PubMed:23903836). During bud formation, associates at the inner side of the plasma membrane of infected cells. {ECO:0000269\|PubMed:23903836, ECO:0000305}.
Ptm:		Phosphorylation is important for oligomerization. {ECO:0000269\|PubMed:24672034}.
Similarity:		Belongs to the pneumovirinae M protein family. {ECO:0000305}.