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PDBsum entry 2vm6
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Immune system
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PDB id
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2vm6
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References listed in PDB file
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Key reference
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Title
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Completing the family portrait of the anti-Apoptotic bcl-2 proteins: crystal structure of human bfl-1 in complex with bim.
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Authors
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M.D.Herman,
T.Nyman,
M.Welin,
L.Lehtiö,
S.Flodin,
L.Trésaugues,
T.Kotenyova,
A.Flores,
P.Nordlund.
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Ref.
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Febs Lett, 2008,
582,
3590-3594.
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PubMed id
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Abstract
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Evasion of apoptosis is recognized as a characteristic of malignant growth.
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged
as potential therapeutic targets due to their critical role in proliferating
cancer cells. Here, we present the crystal structure of Bfl-1, the last
anti-apoptotic Bcl-2 family member to be structurally characterized, in complex
with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim.
The structure reveals distinct features at the peptide-binding site, likely to
define the binding specificity for pro-apoptotic proteins. Superposition of the
Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity
of hydrophobic interactions contributed by the Bim peptide, likely to be the
basis for the multi specificity of Bim for anti-apoptotic proteins.
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