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PDBsum entry 2vim
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Oxidoreductase
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PDB id
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2vim
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References listed in PDB file
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Key reference
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Title
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The fasciola hepatica thioredoxin: high resolution structure reveals two oxidation states.
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Authors
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K.Line,
M.N.Isupov,
E.Garcia-Rodriguez,
G.Maggioli,
F.Parra,
J.A.Littlechild.
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Ref.
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Mol Biochem Parasitol, 2008,
161,
44-48.
[DOI no: ]
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PubMed id
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Abstract
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The Fasciola hepatica thioredoxin protein structure has been determined to 1.45A
resolution. This is the first example of a single crystal structure to show the
active site cysteine residues in both the reduced and disulfide oxidised form.
Consistent with this observation the process of oxidation appears to require
very little rearrangement of the surrounding protein structure. The F. hepatica
thioredoxin structure has been compared to other thioredoxin protein structures
already known and is found to be highly conserved. The F. hepatica protein is
most similar to that of the thioredoxin from its human and animal hosts but it
resembles other parasitic thioredoxins with regard to having no additional
cysteine residues and is therefore not regulated by transient disulfide bond
formation as proposed for thioredoxins from higher eukaryotic species.
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Secondary reference #1
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Title
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Heterologous expression and functional characterization of thioredoxin from fasciola hepatica.
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Authors
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M.Salazar-Calderón,
J.M.Martín-Alonso,
A.D.Ruiz de eguino,
F.Parra.
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Ref.
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Parasitol Res, 2001,
87,
390-395.
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PubMed id
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