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PDBsum entry 2srt
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Hydrolase/hydrolase inhibitor
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PDB id
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2srt
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References listed in PDB file
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Key reference
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Title
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The nmr structure of the inhibited catalytic domain of human stromelysin-1.
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Authors
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P.R.Gooley,
J.F.O'Connell,
A.I.Marcy,
G.C.Cuca,
S.P.Salowe,
B.L.Bush,
J.D.Hermes,
C.K.Esser,
W.K.Hagmann,
J.P.Springer.
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Ref.
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Nat Struct Biol, 1994,
1,
111-118.
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PubMed id
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Abstract
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The three-dimensional structure of the catalytic domain of stromelysin-1
complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods.
The global fold consists of three helices, a five stranded beta-sheet and a
methionine located in a turn near the catalytic histidines, classifying
stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent
zinc binding sites: a catalytic site and a structural site. The inhibitor binds
in an extended conformation. The S1' subsite is a deep hydrophobic pocket,
whereas S2' appears shallow and S3' open.
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Secondary reference #1
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Title
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Secondary structure and zinc ligation of human recombinant short-Form stromelysin by multidimensional heteronuclear nmr.
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Authors
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P.R.Gooley,
B.A.Johnson,
A.I.Marcy,
G.C.Cuca,
S.P.Salowe,
W.K.Hagmann,
C.K.Esser,
J.P.Springer.
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Ref.
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Biochemistry, 1993,
32,
13098-13108.
[DOI no: ]
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PubMed id
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