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PDBsum entry 2spc
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the repetitive segments of spectrin.
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Authors
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Y.Yan,
E.Winograd,
A.Viel,
T.Cronin,
S.C.Harrison,
D.Branton.
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Ref.
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Science, 1993,
262,
2027-2030.
[DOI no: ]
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PubMed id
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Abstract
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The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and
spectrin) contain tandemly repeated segments and form resilient cellular
meshworks by cross-linking actin filaments. The structure of one of the
repetitive segments of alpha-spectrin was determined at a 1.8 angstrom
resolution. A segment consists of a three-helix bundle. A model of the interface
between two tandem segments suggests that hydrophobic interactions between
segments may constrain intersegment flexibility. The helix side chain
interactions explain how mutations that are known to produce hemolytic anemias
disrupt spectrin associations that sustain the integrity of the erythrocyte
membrane.
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