|
|
||
|
|
|
|
|
UniProt functional annotation for P81446 | ||
|
|
|
|
|
|
||
| UniProt code: P81446. |
|
||
| Organism: | |
Viscum album (European mistletoe). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; Santalales; Viscaceae; Viscum. |
|
||
|
||
| Function: | |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4. {ECO:0000269|PubMed:1450445, ECO:0000269|PubMed:15001393, ECO:0000269|PubMed:15182350}. |
|
||
| Catalytic activity: | |
Reaction=Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.; EC=3.2.2.22; |
| Subunit: | |
Disulfide-linked dimer of A and B chains. {ECO:0000269|PubMed:12351890, ECO:0000269|PubMed:12823544, ECO:0000269|PubMed:16508080}. |
| Ptm: | |
The A chain of variant MLA' is not glycosylated. {ECO:0000269|PubMed:12823544}. |
| Pharmaceutical: | |
Due to its immunomodulative effects it is being studied in clinical trials in cancer patients as it may slow the growth of cancer cells and be an effective treatment for solid tumors. |
| Miscellaneous: | |
Several isoforms exist. |
| Similarity: | |
Belongs to the ribosome-inactivating protein family. Type 2 RIP subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.