|
|
||
|
|
|
|
|
UniProt functional annotation for Q7MT22 | ||
|
|
|
|
|
|
||
| UniProt code: Q7MT22. |
|
||
| Organism: | |
Porphyromonas gingivalis (strain ATCC BAA-308 / W83). |
| Taxonomy: | |
Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas. |
|
||
|
||
| Function: | |
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. {ECO:0000256|ARBA:ARBA00002972, ECO:0000256|HAMAP-Rule:MF_00430}. |
|
||
| Catalytic activity: | |
Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000256|ARBA:ARBA00000176, ECO:0000256|HAMAP- Rule:MF_00430}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974, ECO:0000256|HAMAP-Rule:MF_00430}; |
| Cofactor: | |
Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000256|HAMAP-Rule:MF_00430}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|HAMAP-Rule:MF_00430}; |
| Subunit: | |
Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF. {ECO:0000256|ARBA:ARBA00011309, ECO:0000256|HAMAP-Rule:MF_00430}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000256|HAMAP- Rule:MF_00430}; Single-pass membrane protein {ECO:0000256|HAMAP- Rule:MF_00430}. |
| Similarity: | |
Belongs to the NqrF family. {ECO:0000256|ARBA:ARBA00005570, ECO:0000256|HAMAP-Rule:MF_00430}. |
Annotations taken from UniProtKB at the EBI.