|
|
||
|
|
|
|
|
UniProt functional annotation for P17424 | ||
|
|
|
|
|
|
||
| UniProt code: P17424. |
|
||
| Organism: | |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella. |
|
||
|
||
| Function: | |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis. |
|
||
| Catalytic activity: | |
Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10014}; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.; |
| Pathway: | |
Genetic information processing; DNA replication. |
| Subunit: | |
Tetramer of two alpha and two beta subunits. {ECO:0000250}. |
| Similarity: | |
Belongs to the ribonucleoside diphosphate reductase small chain family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.