UniProt functional annotation for P22736



	UniProt functional annotation for P22736

UniProt code: P22736.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12813, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

Subunit: Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1 (PubMed:15459248). Interacts with STK11 (PubMed:22983157). Interacts with IFI27 (PubMed:22427340). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (PubMed:17761950, PubMed:15509776). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (PubMed:17761950). {ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15459248, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157}.

Subcellular location: Nucleus {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157}. Cytoplasm {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340}. Mitochondrion {ECO:0000269|PubMed:17761950}. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340}.

Tissue specificity: Fetal muscle and adult liver, brain and thyroid.

Induction: By growth-stimulating agents.

Ptm: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. {ECO:0000269|PubMed:17360704}.

Ptm: Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1. {ECO:0000269|PubMed:20438716}.

Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:P12813, ECO:0000269\|PubMed:15466594, ECO:0000269\|PubMed:22983157}.


Subunit:		Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1 (PubMed:15459248). Interacts with STK11 (PubMed:22983157). Interacts with IFI27 (PubMed:22427340). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (PubMed:17761950, PubMed:15509776). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (PubMed:17761950). {ECO:0000250\|UniProtKB:P22829, ECO:0000269\|PubMed:15459248, ECO:0000269\|PubMed:15509776, ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:22427340, ECO:0000269\|PubMed:22983157}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:15509776, ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:20438716, ECO:0000269\|PubMed:22427340, ECO:0000269\|PubMed:22983157}. Cytoplasm {ECO:0000269\|PubMed:15509776, ECO:0000269\|PubMed:20438716, ECO:0000269\|PubMed:22427340}. Mitochondrion {ECO:0000269\|PubMed:17761950}. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:22427340}.
Tissue specificity:		Fetal muscle and adult liver, brain and thyroid.
Induction:		By growth-stimulating agents.
Ptm:		Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. {ECO:0000269\|PubMed:17360704}.
Ptm:		Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1. {ECO:0000269\|PubMed:20438716}.
Similarity:		Belongs to the nuclear hormone receptor family. NR4 subfamily. {ECO:0000305}.