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UniProt functional annotation for Q99AU2 | ||
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| UniProt code: Q99AU2. |
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| Organism: | |
Hepatitis C virus subtype 1b. |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus. |
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| Function: | |
RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication. {ECO:0000256|ARBA:ARBA00023584}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000256|ARBA:ARBA00023556}; |
| Catalytic activity: | |
[Serine protease/helicase NS3]: Reaction=Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.; EC=3.4.21.98; Evidence={ECO:0000256|ARBA:ARBA00023535}; |
| Catalytic activity: | |
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence={ECO:0000256|ARBA:ARBA00023538}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947}; |
| Subcellular location: | |
Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}. Host cell membrane {ECO:0000256|ARBA:ARBA00004165}. Host cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host cytoplasm, host perinuclear region {ECO:0000256|ARBA:ARBA00004407}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004291}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004291}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004517}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004517}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004482}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004482}. Host lipid droplet {ECO:0000256|ARBA:ARBA00004338}. Host mitochondrion {ECO:0000256|ARBA:ARBA00004181}. Host mitochondrion membrane {ECO:0000256|ARBA:ARBA00004458}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004458}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Lipid droplet {ECO:0000256|ARBA:ARBA00004502}. Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|ARBA:ARBA00004370}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004583}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004583}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Virion {ECO:0000256|ARBA:ARBA00004328}. Virion membrane {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004563}. |
| Similarity: | |
Belongs to the hepacivirus polyprotein family. {ECO:0000256|ARBA:ARBA00008286}. |
Annotations taken from UniProtKB at the EBI.