UniProt functional annotation for Q9D020



	UniProt functional annotation for Q9D020

UniProt code: Q9D020.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. {ECO:0000250|UniProtKB:Q9H0P0}.

Catalytic activity: Reaction=H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate; Xref=Rhea:RHEA:37107, ChEBI:CHEBI:15377, ChEBI:CHEBI:20794, ChEBI:CHEBI:43474, ChEBI:CHEBI:58285; EC=3.1.3.91; Evidence={ECO:0000250|UniProtKB:Q9H0P0};

Catalytic activity: Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence={ECO:0000269|PubMed:16672222};

Subunit: Monomer.

Subcellular location: Cytoplasm {ECO:0000305}.

Tissue specificity: Isoform 2 is highly expressed in the brain, heart, spleen, kidney and blood. Isoform 2 is expressed (at protein level) in the spleen, skeletal muscle and gastrointestinal epithelia.

Developmental stage: Isoform 2 is weakly expressed from 7.5 dpc and the expression level steadily increases through gestation. At 9.5 dpc and 10.5 dpc is first detected colocalizing with embryonic blood cells within the region of the septum transversum and within the cardiac chambers and dorsal aorta. At 12.5 dpc expression is found in the ventral neural tube and in the trigeminal ganglia and in the liver and dorsal root ganglia. Expression persists in the liver, dorsal root and trigeminal ganglia at 13.5 dpc and weaker expression becomes apparent in cardiac and skeletal muscle. At 16.5 dpc expression is detected in liver, myocardium, tongue, bronchial epithelium, gastrointestinal epithelium, cartilage and forebrain neuroepithelium.

Similarity: Belongs to the pyrimidine 5'-nucleotidase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. {ECO:0000250\|UniProtKB:Q9H0P0}.


Catalytic activity:		Reaction=H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate; Xref=Rhea:RHEA:37107, ChEBI:CHEBI:15377, ChEBI:CHEBI:20794, ChEBI:CHEBI:43474, ChEBI:CHEBI:58285; EC=3.1.3.91; Evidence={ECO:0000250\|UniProtKB:Q9H0P0};
Catalytic activity:		Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence={ECO:0000269\|PubMed:16672222};
Subunit:		Monomer.
Subcellular location:		Cytoplasm {ECO:0000305}.
Tissue specificity:		Isoform 2 is highly expressed in the brain, heart, spleen, kidney and blood. Isoform 2 is expressed (at protein level) in the spleen, skeletal muscle and gastrointestinal epithelia.
Developmental stage:		Isoform 2 is weakly expressed from 7.5 dpc and the expression level steadily increases through gestation. At 9.5 dpc and 10.5 dpc is first detected colocalizing with embryonic blood cells within the region of the septum transversum and within the cardiac chambers and dorsal aorta. At 12.5 dpc expression is found in the ventral neural tube and in the trigeminal ganglia and in the liver and dorsal root ganglia. Expression persists in the liver, dorsal root and trigeminal ganglia at 13.5 dpc and weaker expression becomes apparent in cardiac and skeletal muscle. At 16.5 dpc expression is detected in liver, myocardium, tongue, bronchial epithelium, gastrointestinal epithelium, cartilage and forebrain neuroepithelium.
Similarity:		Belongs to the pyrimidine 5'-nucleotidase family. {ECO:0000305}.