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UniProt functional annotation for P02754 | ||
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| UniProt code: P02754. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule. |
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| Subunit: | |
Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms (PubMed:9115437, PubMed:9760236, PubMed:8601463, PubMed:10595563). Interaction with LMBR1L which mediates the endocytosis of LGB has been observed in PubMed:17991420, but not in PubMed:23964685 (PubMed:17991420, PubMed:23964685). {ECO:0000269|PubMed:10595563, ECO:0000269|PubMed:17991420, ECO:0000269|PubMed:23964685, ECO:0000269|PubMed:8601463, ECO:0000269|PubMed:9115437, ECO:0000269|PubMed:9760236}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Synthesized in mammary gland and secreted in milk. |
| Ptm: | |
Alternate disulfide bonds occur in equal amounts in all variants examined. |
| Allergen: | |
Causes an allergic reaction in human. Is one of the causes of cow's milk allergy. |
| Miscellaneous: | |
The B variant sequence is shown. |
| Similarity: | |
Belongs to the calycin superfamily. Lipocalin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.