UniProt functional annotation for P9WN95



	UniProt functional annotation for P9WN95

UniProt code: P9WN95.

Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).

Taxonomy: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.

Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. {ECO:0000255|HAMAP-Rule:MF_00909}.

Subunit: Homodimer (PubMed:23888039). Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity). Interacts with FhaB and FtsQ in a PknA-dependent manner. Initial interaction between FtsZ and FhaB is necessary for ternary FtsZ-FhaB-FtsQ complex formation. {ECO:0000255|HAMAP-Rule:MF_00909, ECO:0000269|PubMed:15342249, ECO:0000269|PubMed:18479968, ECO:0000269|PubMed:20066037, ECO:0000269|PubMed:23888039}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.

Ptm: Phosphorylated by PknA. Phosphorylation is required for FtsZ-FhaB interaction. {ECO:0000269|PubMed:20066037}.

Similarity: Belongs to the FtsZ family. {ECO:0000255|HAMAP- Rule:MF_00909}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Taxonomy:		Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.



Function:		Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. {ECO:0000255\|HAMAP-Rule:MF_00909}.


Subunit:		Homodimer (PubMed:23888039). Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity). Interacts with FhaB and FtsQ in a PknA-dependent manner. Initial interaction between FtsZ and FhaB is necessary for ternary FtsZ-FhaB-FtsQ complex formation. {ECO:0000255\|HAMAP-Rule:MF_00909, ECO:0000269\|PubMed:15342249, ECO:0000269\|PubMed:18479968, ECO:0000269\|PubMed:20066037, ECO:0000269\|PubMed:23888039}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255\|HAMAP-Rule:MF_00909}.
Ptm:		Phosphorylated by PknA. Phosphorylation is required for FtsZ-FhaB interaction. {ECO:0000269\|PubMed:20066037}.
Similarity:		Belongs to the FtsZ family. {ECO:0000255\|HAMAP- Rule:MF_00909}.