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UniProt functional annotation for Q15366 | ||
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| UniProt code: Q15366. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509}. |
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| Function: | |
(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
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| Subunit: | |
Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with IFIH1 and RNF135. Interacts with MAVS (via C-terminus) and ITCH (via WW domains). {ECO:0000269|PubMed:16186123, ECO:0000269|PubMed:17426136, ECO:0000269|PubMed:17526645, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19881509}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:19029303}. Cytoplasm {ECO:0000269|PubMed:19029303}. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. |
| Tissue specificity: | |
Detected in all tissues examined. |
| Domain: | |
The KH domains mediates poly(C) binding. |
| Ptm: | |
Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. |
| Ptm: | |
(Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD. {ECO:0000269|PubMed:24371074}. |
| Sequence caution: | |
Sequence=BAD92062.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.