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PDBsum entry 2px4
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the murray valley encephalitis virus ns5 methyltransferase domain in complex with cap analogues.
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Authors
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R.Assenberg,
J.Ren,
A.Verma,
T.S.Walter,
D.Alderton,
R.J.Hurrelbrink,
S.D.Fuller,
S.Bressanelli,
R.J.Owens,
D.I.Stuart,
J.M.Grimes.
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Ref.
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J Gen Virol, 2007,
88,
2228-2236.
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PubMed id
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Abstract
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We have determined the high resolution crystal structure of the
methyltransferase domain of the NS5 polypeptide from the Murray Valley
encephalitis virus. This domain is unusual in having both the N7 and 2'-O
methyltransferase activity required for Cap 1 synthesis. We have also determined
structures for complexes of this domain with nucleotides and cap analogues
providing information on cap binding, based on which we suggest a model of how
the sequential methylation of the N7 and 2'-O groups of the cap may be
coordinated.
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