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UniProt functional annotation for Q60819 | ||
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| UniProt code: Q60819. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q13261, ECO:0000269|PubMed:17947230}. |
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| Subunit: | |
The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK (By similarity). {ECO:0000250|UniProtKB:Q13261}. |
| Subcellular location: | |
Membrane {ECO:0000250|UniProtKB:Q13261}; Single- pass type I membrane protein {ECO:0000250|UniProtKB:Q13261}. Nucleus membrane {ECO:0000250|UniProtKB:Q13261}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13261}. Cell surface {ECO:0000250|UniProtKB:Q13261}. |
| Subcellular location: | |
[Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space {ECO:0000250}. |
| Tissue specificity: | |
Widely expressed. {ECO:0000269|PubMed:12885940, ECO:0000269|PubMed:7641685}. |
| Ptm: | |
N-glycosylated and O-glycosylated. {ECO:0000250|UniProtKB:Q13261}. |
| Ptm: | |
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (By similarity). It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity). {ECO:0000250|UniProtKB:Q13261}. |
Annotations taken from UniProtKB at the EBI.