|
|
||
|
|
|
|
|
UniProt functional annotation for Q57688 | ||
|
|
|
|
|
|
||
| UniProt code: Q57688. |
|
||
| Organism: | |
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii). |
| Taxonomy: | |
Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus. |
|
||
|
||
| Function: | |
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. {ECO:0000250|UniProtKB:P76422}. |
|
||
|
||
| Function: | |
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). {ECO:0000250|UniProtKB:Q9WZP7}. |
|
||
| Catalytic activity: | |
Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2- methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+); Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892, ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.1.49; Evidence={ECO:0000250|UniProtKB:P76422}; |
| Catalytic activity: | |
Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4- amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP; Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7; Evidence={ECO:0000250|UniProtKB:P76422}; |
| Catalytic activity: | |
Reaction=2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate; Xref=Rhea:RHEA:47844, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33019, ChEBI:CHEBI:37575, ChEBI:CHEBI:57841, ChEBI:CHEBI:62899; EC=2.5.1.3; Evidence={ECO:0000250|UniProtKB:Q9WZP7}; |
| Catalytic activity: | |
Reaction=2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2- methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate; Xref=Rhea:RHEA:47848, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33019, ChEBI:CHEBI:37575, ChEBI:CHEBI:57841, ChEBI:CHEBI:62890; EC=2.5.1.3; Evidence={ECO:0000250|UniProtKB:Q9WZP7}; |
| Catalytic activity: | |
Reaction=4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl- 5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate; Xref=Rhea:RHEA:22328, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37575, ChEBI:CHEBI:57841, ChEBI:CHEBI:58296; EC=2.5.1.3; Evidence={ECO:0000250|UniProtKB:Q9WZP7}; |
| Pathway: | |
Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4- amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D- ribosyl)imidazole. |
| Pathway: | |
Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1. |
| Similarity: | |
In the N-terminal section; belongs to the ThiD family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the ThiN family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAB98222.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.