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PDBsum entry 2pgd
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Oxidoreductase (choh(d)-NADP+(a))
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PDB id
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2pgd
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References listed in PDB file
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Key reference
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Title
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The structure of 6-Phosphogluconate dehydrogenase refined at 2.5 a resolution.
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Authors
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M.J.Adams,
S.Gover,
R.Leaback,
C.Phillips,
D.O.Somers.
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Ref.
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Acta Crystallogr B, 1991,
47,
817-820.
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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The three-dimensional structure of ovine 6-phosphogluconate dehydrogenase,
refined at 2.5 A resolution with a residual for all data of 18.5%, is reported.
This model, based on improved diffraction data and a corrected sequence,
supersedes that reported earlier. Each subunit of the dimer has three domains: a
beta-alpha-beta domain binds NADP; an all alpha domain provides much of the
dimer interface; the C-terminal tail burrows into the second subunit.
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Secondary reference #1
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Title
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Crystallographic study of coenzyme, Coenzyme analogue and substrate binding in 6-Phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
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Authors
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M.J.Adams,
G.H.Ellis,
S.Gover,
C.E.Naylor,
C.Phillips.
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Ref.
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Structure, 1994,
2,
651-668.
[DOI no: ]
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PubMed id
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Figure 8.
Figure 8. Stereo pair showing Arg33 in its conformation in the
apo-enzyme (blue) and in binary complexes (red), and
demonstrating its role in forming the adenine pocket. Figure
8. Stereo pair showing Arg33 in its conformation in the
apo-enzyme (blue) and in binary complexes (red), and
demonstrating its role in forming the adenine pocket.
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Figure 14.
Figure 14. Steps of the general base–acid mechanism for 6PG
oxidative decarboxylation by 6PGDH (after Berdis and Cook [21]).
Figure 14. Steps of the general base–acid mechanism for 6PG
oxidative decarboxylation by 6PGDH (after Berdis and Cook
[[3]21]).
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The above figures are
reproduced from the cited reference
with permission from Cell Press
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Secondary reference #2
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Title
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The structure of 6-Phosphogluconate dehydrogenase refined at 2.5 a resolution.
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Authors
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M.J.Adams,
S.Gover,
R.Leaback,
C.Phillips,
D.O.Somers.
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Ref.
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Acta Crystallogr B, 1991,
47,
817-820.
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PubMed id
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