UniProt functional annotation for P03081



	UniProt functional annotation for P03081

UniProt code: P03081.

Organism: Simian virus 40 (SV40).

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus.

Function: Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host eIF4E-binding protein EIF4EBP1 leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. {ECO:0000269|PubMed:15680424, ECO:0000269|PubMed:15890927, ECO:0000269|PubMed:17936323, ECO:0000269|PubMed:8794333, ECO:0000269|PubMed:8917510}.

Subunit: Interacts with host PPP2R1A; the interaction inhibits PP2A activity. {ECO:0000269|PubMed:1706474, ECO:0000269|PubMed:8107228}.

Subcellular location: Host cytoplasm {ECO:0000269|PubMed:6323762}. Host nucleus {ECO:0000269|PubMed:6323762}.

Domain: The common region of SV40 ST, 17kT and LT proteins comprises the J domain. This domain is essential for multiple viral activities, including virion assembly, viral DNA replication, transformation and transcriptional activation. This domain is also required for cyclin A- transactivating activity of ST. {ECO:0000269|PubMed:9108037}.

Miscellaneous: [Isoform Small t antigen]: Produced by alternative splicing.

Annotations taken from UniProtKB at the EBI.


Organism:		Simian virus 40 (SV40).
Taxonomy:		Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus.



Function:		Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host eIF4E-binding protein EIF4EBP1 leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. {ECO:0000269\|PubMed:15680424, ECO:0000269\|PubMed:15890927, ECO:0000269\|PubMed:17936323, ECO:0000269\|PubMed:8794333, ECO:0000269\|PubMed:8917510}.


Subunit:		Interacts with host PPP2R1A; the interaction inhibits PP2A activity. {ECO:0000269\|PubMed:1706474, ECO:0000269\|PubMed:8107228}.
Subcellular location:		Host cytoplasm {ECO:0000269\|PubMed:6323762}. Host nucleus {ECO:0000269\|PubMed:6323762}.
Domain:		The common region of SV40 ST, 17kT and LT proteins comprises the J domain. This domain is essential for multiple viral activities, including virion assembly, viral DNA replication, transformation and transcriptional activation. This domain is also required for cyclin A- transactivating activity of ST. {ECO:0000269\|PubMed:9108037}.
Miscellaneous:		[Isoform Small t antigen]: Produced by alternative splicing.