 |
PDBsum entry 2per
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Electron transport
|
PDB id
|
|
|
|
2per
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.
|
|
|
Authors
|
|
W.Mi,
Y.H.Liang,
L.Li,
X.D.Su.
|
|
|
Ref.
|
|
Proteins, 2008,
71,
509-513.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
No abstract given.
|
|
|
|
|
|
|
|
Figure 1.
Figure 1. Structure of human CLIC2. (A) Structure based
sequence alignment of human CLIC1-6 and DHAR2, DHAR3 from A.
thaliana. Identical and conserved residues are colored in red
and yellow, respectively. CXXC motif is colored in cyan and
marked by upwards triangles. The additional N-terminal sequences
of CLIC5 and CLIC6 were truncated. (B) Overall structure of
CLIC2. N-terminal domain is colored in red; C-terminal domain in
green, the  joint
loop  in
yellow, the foot
loop in
blue, disulfide bond between Cys^30 and Cys^33 is showed as
stick (yellow). (C) Structure superimposition of CLIC1 (yellow),
CLIC4 (red) structures on CLIC2 (green). Disulfide bond in CLIC2
is showed in stick (yellow).
|
|
Figure 2.
Figure 2. Disulfide bond between Cys^30 and Cys^33 and the
electrostatic potential surface of CLIC2. (A) Structure
comparison between the N-terminal domain of CLIC2 (green) and
pig glutaredoxin (magenta), poxviral glutaredoxin (cyan). The
disulfide bond of CLIC2 is showed in stick (yellow). (B) 2Fo-Fc
electron density map and stick diagram of the disulfide bond in
human CLIC2. (C) Structure comparison of disulfide bonds between
CLIC2 (green) with pig glutaredoxin (magenta), poxviral
glutaredoxin (cyan). (D) The electrostatic potential surface of
CLIC2 and foot loop insertion into the cavity of the neighbor
molecule.
|
|
|
|
|
|
The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
71,
509-513)
copyright 2008.
|
|
|
|
|
|
|
