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PDBsum entry 2pd4
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Oxidoreductase
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PDB id
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2pd4
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References listed in PDB file
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Key reference
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Title
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Crystal structure of the helicobacter pylori enoyl-Acyl carrier protein reductase in complex with hydroxydiphenyl ether compounds, Triclosan and diclosan.
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Authors
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H.H.Lee,
J.Moon,
S.W.Suh.
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Ref.
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Proteins, 2007,
69,
691-694.
[DOI no: ]
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PubMed id
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Abstract
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No abstract given.
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Figure 1.
Figure 1. Monomer and tetramer structures of H. pylori ENR and
electron density maps of the bound ligands. (A) Monomer
structure. Secondary structure elements were defined by PyMOL
(DeLano, 2002, The PyMOL Molecular Graphics System,
http://pymol.sourceforge.net/). NAD^+ and triclosan bound to the
active site of subunit A are shown as ball-and-stick models. (B)
Tetrameric architecture. NAD^+ and triclosan are shown. (C)
2F[o]-F[c] electron density maps of the bound ligands,
superimposed on triclosan (subunit A), diclosan (subunit A), and
NAD^+ (subunit A of the triclosan complex). (D) Superposition of
triclosan (cyan) and diclosan (purple). Phenolic rings (ring A)
of triclosan and diclosan are superimposed.
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Figure 2.
Figure 2. Binding mode of triclosan, diclosan, and NAD^+. (A)
Superposition of H. pylori ENR (subunit A of the triclosan
complex, colored in red) with ENRs from E. coli (PDB ID code
1C14, colored in yellow), M. tuberculosis (PDB ID code 1P45,
colored in pink), B. napus (PDB ID code 1D7O, colored in cyan),
and P. falciparum (PDB ID code 1UH5, colored in green) ENRs
(monomer A). (B) Binding site of triclosan and NAD^+ in subunit
A. (C) Binding site of diclosan and NAD^+ in subunit A.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2007,
69,
691-694)
copyright 2007.
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