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UniProt functional annotation for Q9UI42 | ||
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| UniProt code: Q9UI42. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). {ECO:0000269|PubMed:10383164, ECO:0000269|PubMed:20385563}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:22294694}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:22294694}; |
| Activity regulation: | |
Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion. {ECO:0000269|PubMed:22294694}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe {ECO:0000269|PubMed:20385563}; KM=19.4 uM for 3-(2-furyl)acryloyl-Phe-Leu {ECO:0000269|PubMed:20385563}; KM=23.3 uM for 3-(2-furyl)acryloyl-Phe-Ile {ECO:0000269|PubMed:20385563}; KM=40.4 uM for 3-(2-furyl)acryloyl-Phe-Met {ECO:0000269|PubMed:20385563}; KM=57.3 uM for 3-(2-furyl)acryloyl-Phe-Val {ECO:0000269|PubMed:20385563}; KM=0.329 uM for neurotensin {ECO:0000269|PubMed:20385563}; KM=9.23 uM for Met-enkephalin-Arg-Phe {ECO:0000269|PubMed:20385563}; pH dependence: Optimum pH is 8.5-9. {ECO:0000269|PubMed:20385563}; |
| Subunit: | |
Monomer. Interacts with LXN. {ECO:0000269|PubMed:15738388, ECO:0000269|PubMed:16091843, ECO:0000269|PubMed:22294694}. |
| Subcellular location: | |
Secreted {ECO:0000250}. |
| Tissue specificity: | |
Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele. |
| Induction: | |
Up-regulated by inhibitors of histone dacetylation. {ECO:0000269|PubMed:10383164}. |
| Similarity: | |
Belongs to the peptidase M14 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.