|
|
||
|
|
|
|
|
UniProt functional annotation for Q9STG6 | ||
|
|
|
|
|
|
||
| UniProt code: Q9STG6. |
|
||
| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
|
||
|
||
| Function: | |
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA. {ECO:0000269|PubMed:20227352}. |
|
||
| Catalytic activity: | |
Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) per trimer.; |
| Pathway: | |
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:17565183}. |
| Miscellaneous: | |
Silencing of DUT leads to high seedling mortality and affects plant growth and flower organ morphology in surviving plants. |
| Similarity: | |
Belongs to the dUTPase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.