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UniProt functional annotation for Q97QZ2 | ||
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| UniProt code: Q97QZ2. |
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| Organism: | |
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. |
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| Function: | |
Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the toxic effect of cognate toxin PezT. Represses transcription of its own operon, PezT acts as a corepressor, considerably increasing repression. {ECO:0000269|PubMed:17488720, ECO:0000269|PubMed:21445328}. |
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| Subunit: | |
Probably a homodimer, forms a PezA(2)PezT(2) heterotetramer. The heterotetramer is much more stable than either of the proteins alone, and a specific mechanism may be necessary to liberate the toxin. {ECO:0000269|PubMed:17488720, ECO:0000269|PubMed:20442221}. |
| Induction: | |
Conflicting data is available; found to be a member of the pezAT operon (upon ectopic expression in E.coli); in S.pneumoniae strain 0100993 is found in a monocistronic operon. |
Annotations taken from UniProtKB at the EBI.