UniProt functional annotation for P55769



	UniProt functional annotation for P55769

UniProt code: P55769.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166}.

Subunit: Identified in the spliceosome B complex (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:26912367). Interacts with RAD17 and PRPF31 (PubMed:10593953, PubMed:17412961, PubMed:21784869). The complex formed by SNU13 and PRPF31 binds U4 snRNA (PubMed:17412961). The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes (PubMed:21784869). {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:21784869, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.

Subcellular location: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}. Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000269|PubMed:10593953}.

Tissue specificity: Ubiquitous.

Similarity: Belongs to the eukaryotic ribosomal protein eL8 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961). {ECO:0000269\|PubMed:10545122, ECO:0000269\|PubMed:17412961, ECO:0000269\|PubMed:28781166}.


Subunit:		Identified in the spliceosome B complex (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:26912367). Interacts with RAD17 and PRPF31 (PubMed:10593953, PubMed:17412961, PubMed:21784869). The complex formed by SNU13 and PRPF31 binds U4 snRNA (PubMed:17412961). The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes (PubMed:21784869). {ECO:0000269\|PubMed:10593953, ECO:0000269\|PubMed:16723661, ECO:0000269\|PubMed:17412961, ECO:0000269\|PubMed:21784869, ECO:0000269\|PubMed:26912367, ECO:0000269\|PubMed:28781166}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:26912367, ECO:0000269\|PubMed:28781166}. Nucleus, nucleolus {ECO:0000269\|PubMed:10593953, ECO:0000269\|PubMed:12429849, ECO:0000269\|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000269\|PubMed:10593953}.
Tissue specificity:		Ubiquitous.
Similarity:		Belongs to the eukaryotic ribosomal protein eL8 family. {ECO:0000305}.