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UniProt functional annotation for P04303 | ||
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| UniProt code: P04303. |
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| Organism: | |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)). |
| Taxonomy: | |
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus. |
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| Function: | |
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:8291232}. |
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| Catalytic activity: | |
Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; |
| Subunit: | |
Homodimer (By similarity). Interacts with protein A20. Component of the Uracil-DNA glycosylase(UDG)-A20-polymerase complex; A20 and UDG form a heterodimeric processivity factor that associates with E9 to form the processive polymerase holoenzyme. {ECO:0000250, ECO:0000269|PubMed:16326701, ECO:0000269|PubMed:21572084}. |
| Similarity: | |
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.