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UniProt functional annotation for P12807 | ||
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| UniProt code: P12807. |
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| Organism: | |
Pichia angusta (Yeast) (Hansenula polymorpha). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Pichiaceae; Ogataea. |
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| Catalytic activity: | |
Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+); Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938, ChEBI:CHEBI:58001; EC=1.4.3.21; Evidence={ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}; |
| Cofactor: | |
Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:10933787}; Note=Binds 1 copper ion per subunit. Can also use zinc ion as cofactor (PubMed:10933787). {ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}; |
| Cofactor: | |
Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence={ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}; Note=Contains 1 topaquinone per subunit. {ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q43077}; Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250|UniProtKB:Q43077}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:7556609, ECO:0000269|PubMed:9551552}. |
| Subcellular location: | |
Peroxisome {ECO:0000305|PubMed:9551552}. |
| Induction: | |
By methylamine. |
| Ptm: | |
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000269|PubMed:10933787, ECO:0000269|PubMed:9551552}. |
| Similarity: | |
Belongs to the copper/topaquinone oxidase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.