PDBsum entry 2of4

Transferase

PDB id: 2of4

Contents

Protein chain

271 a.a.

Ligands

979

Waters ×44

References listed in PDB file

Key reference

• Title: Discovery of novel 2,3-Diarylfuro[2,3-B]pyridin-4-Amines as potent and selective inhibitors of lck: synthesis, Sar, And pharmacokinetic properties.
• Authors: M.W.Martin, J.Newcomb, J.J.Nunes, J.E.Bemis, D.C.Mcgowan, R.D.White, J.L.Buchanan, E.F.Dimauro, C.Boucher, T.Faust, F.Hsieh, X.Huang, J.H.Lee, S.Schneider, S.M.Turci, X.Zhu.
• Ref.: Bioorg Med Chem Lett, 2007, 17, 2299-2304. [DOI no: 10.1016/j.bmcl.2007.01.048]
• PubMed id: 17276681

Abstract

2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.