UniProt functional annotation for Q15599



	UniProt functional annotation for Q15599

UniProt code: Q15599.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}.

Subunit: Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2. Interacts with MCC and PODXL. Interacts with SGK1 and KCNJ1/ROMK1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5. {ECO:0000250, ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:12444019, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:15642748, ECO:0000269|PubMed:16615918, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:9054412, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9671706}.

Subcellular location: Endomembrane system {ECO:0000269|PubMed:9054412}; Peripheral membrane protein {ECO:0000269|PubMed:9054412}. Nucleus {ECO:0000269|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.

Tissue specificity: Widely expressed. {ECO:0000269|PubMed:9054412, ECO:0000269|PubMed:9096337}.

Sequence caution: Sequence=AAH14513.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA90511.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269\|PubMed:10455146, ECO:0000269\|PubMed:18829453, ECO:0000269\|PubMed:9096337}.


Subunit:		Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2. Interacts with MCC and PODXL. Interacts with SGK1 and KCNJ1/ROMK1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5. {ECO:0000250, ECO:0000269\|PubMed:10455146, ECO:0000269\|PubMed:12444019, ECO:0000269\|PubMed:14623317, ECO:0000269\|PubMed:15143197, ECO:0000269\|PubMed:15642748, ECO:0000269\|PubMed:16615918, ECO:0000269\|PubMed:19555689, ECO:0000269\|PubMed:9054412, ECO:0000269\|PubMed:9096337, ECO:0000269\|PubMed:9671706}.
Subcellular location:		Endomembrane system {ECO:0000269\|PubMed:9054412}; Peripheral membrane protein {ECO:0000269\|PubMed:9054412}. Nucleus {ECO:0000269\|PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.
Tissue specificity:		Widely expressed. {ECO:0000269\|PubMed:9054412, ECO:0000269\|PubMed:9096337}.
Sequence caution:		Sequence=AAH14513.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA90511.1; Type=Frameshift; Evidence={ECO:0000305};