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UniProt functional annotation for P28037 | ||
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| UniProt code: P28037. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Catalytic activity: | |
Reaction=(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8- tetrahydrofolate + CO2 + H(+) + NADPH; Xref=Rhea:RHEA:10180, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57453, ChEBI:CHEBI:57454, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.6; Evidence={ECO:0000269|PubMed:14729668, ECO:0000269|PubMed:17302434}; |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:17302434, ECO:0000269|PubMed:21540484, ECO:0000269|PubMed:7822273}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:3392008}. |
| Similarity: | |
In the N-terminal section; belongs to the GART family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.