UniProt functional annotation for O34966

UniProt code: O34966.

Organism: Bacillus subtilis (strain 168).
Taxonomy: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
 
Function: Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable). ZnuABC-mediated zinc transport is required for comF expression and competence development. {ECO:0000269|PubMed:21813502, ECO:0000269|PubMed:9811636, ECO:0000305}.
 
Subunit: The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA). {ECO:0000305}.
Subcellular location: Cell membrane {ECO:0000305|PubMed:14730579}; Lipid-anchor {ECO:0000305|PubMed:14730579}.
Induction: Repressed by zinc via the metallo-regulatory protein Zur. {ECO:0000269|PubMed:12426338, ECO:0000269|PubMed:9811636}.
Disruption phenotype: Cells lacking this gene grow slowly in zinc- deficient medium; this effect is suppressed upon addition of exogenous Zn(2+). Growth is slower yet in a double knockout with YciC. Disruption results in low transformability. {ECO:0000269|PubMed:21813502, ECO:0000269|PubMed:9811636}.
Similarity: Belongs to the bacterial solute-binding protein 9 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.