|
|
||
|
|
|
|
|
UniProt functional annotation for Q9Y235 | ||
|
|
|
|
|
|
||
| UniProt code: Q9Y235. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:17187054, ECO:0000269|PubMed:21496894}. |
|
||
| Catalytic activity: | |
Reaction=cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA; Xref=Rhea:RHEA:21772, Rhea:RHEA- COMP:13888, Rhea:RHEA-COMP:13889, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:65315, ChEBI:CHEBI:82748; EC=3.5.4.36; Evidence={ECO:0000269|PubMed:17187054}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:17187054}; Note=Binds 1 Zn(2+) ion per subunit. {ECO:0000269|PubMed:17187054}; |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:17187054}. |
| Tissue specificity: | |
Expressed exclusively in heart and skeletal muscle. |
| Similarity: | |
Belongs to the cytidine and deoxycytidylate deaminase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.