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UniProt functional annotation for Q84BQ9 | ||
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| UniProt code: Q84BQ9. |
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| Organism: | |
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8). |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
Methylates ribosomal protein L11 (PubMed:15317787). Preferentially recognizes free L11 before its incorporation into 50S subunits (PubMed:15317787). This function is dispensable for growth and thermostability (PubMed:15317787). {ECO:0000269|PubMed:15317787}. |
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| Catalytic activity: | |
Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence={ECO:0000255|HAMAP- Rule:MF_00735, ECO:0000305|PubMed:15317787}; |
| Catalytic activity: | |
Reaction=an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L- methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:62916, Rhea:RHEA- COMP:10636, Rhea:RHEA-COMP:16230, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:78597, ChEBI:CHEBI:146135; Evidence={ECO:0000305|PubMed:15317787}; |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00735}. |
| Domain: | |
Contains an N-terminal substrate recognition domain and a C- terminal methyltransferase domain, connected by a flexible linker. {ECO:0000269|PubMed:17215866, ECO:0000269|PubMed:18611379}. |
| Disruption phenotype: | |
Mutant contains unmethylated protein L11 (PubMed:15317787). Null mutant is perfectly viable (PubMed:15317787). {ECO:0000269|PubMed:15317787}. |
| Similarity: | |
Belongs to the methyltransferase superfamily. PrmA family. {ECO:0000255|HAMAP-Rule:MF_00735, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.