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UniProt functional annotation for P0AG18 | ||
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| UniProt code: P0AG18. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:8117684}. |
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| Catalytic activity: | |
Reaction=5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate; Xref=Rhea:RHEA:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:58730, ChEBI:CHEBI:77657; EC=5.4.99.18; Evidence={ECO:0000255|HAMAP- Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=140 uM for N5-CAIR {ECO:0000269|PubMed:8117684}; |
| Pathway: | |
Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:8117684}. |
| Subunit: | |
Homooctamer. {ECO:0000269|PubMed:10574791}. |
| Similarity: | |
Belongs to the AIR carboxylase family. Class I subfamily. {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.