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PDBsum entry 2n9h
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References listed in PDB file
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Key reference
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Title
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Glucose-Nucleobase pseudo base pairs: biomolecular interactions within DNA.
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Authors
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E.Vengut-Climent,
I.Gómez-Pinto,
R.Lucas,
P.Peñalver,
A.Aviñó,
C.Fonseca guerra,
F.M.Bickelhaupt,
R.Eritja,
C.González,
J.C.Morales.
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Ref.
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Angew Chem Int Ed Engl, 2016,
55,
8643-8647.
[DOI no: ]
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PubMed id
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Abstract
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Noncovalent forces rule the interactions between biomolecules. Inspired by a
biomolecular interaction found in aminoglycoside-RNA recognition,
glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a
6-deoxyglucose insertion are able to hybridize with their complementary strand,
thus exhibiting a preference for purine nucleobases. Although the resulting
double helices are less stable than natural ones, they present only minor local
distortions. 6-Deoxyglucose stays fully integrated in the double helix and its
OH groups form two hydrogen bonds with the opposing guanine. This
6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry.
Quantum chemical calculations indicate that glucose-purine pairs are as stable
as a natural T-A pair.
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Headers
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