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PDBsum entry 2n93
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Lipid binding protein
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PDB id
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2n93
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References listed in PDB file
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Key reference
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Title
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1h, 15n and 13c resonance assignments of light organ-Associated fatty acid-Binding protein of taiwanese fireflies.
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Authors
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K.L.Tseng,
Y.Z.Lee,
Y.R.Chen,
P.C.Lyu.
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Ref.
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Biomol Nmr Assign, 2016,
10,
71-74.
[DOI no: ]
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PubMed id
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Abstract
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Fatty acid-binding proteins (FABPs) are a family of proteins that modulate the
transfer of various fatty acids in the cytosol and constitute a significant
portion in many energy-consuming cells. The ligand binding properties and
specific functions of a particular type of FABP seem to be diverse and depend on
the respective binding cavity as well as the cell type from which this protein
is derived. Previously, a novel FABP (lcFABP; lc: Luciola cerata) was identified
in the light organ of Taiwanese fireflies. The lcFABP was proved to possess
fatty acids binding capabilities, especially for fatty acids of length C14-C18.
However, the structural details are unknown, and the structure-function
relationship has remained to be further investigated. In this study, we finished
the (1)H, (15)N and (13)C chemical shift assignments of (15)N/(13)C-enriched
lcFABP by solution NMR spectroscopy. In addition, the secondary structure
distribution was revealed based on the backbone N, H, Cα, Hα, C and side chain
Cβ assignments. These results can provide the basis for further structural
exploration of lcFABP.
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