UniProt functional annotation for P01213



	UniProt functional annotation for P01213

UniProt code: P01213.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.

Function: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.

Function: Leumorphin has a typical opiod activity and may have anti- apoptotic effect. {ECO:0000250}.

Subcellular location: Secreted.

Ptm: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Disease: Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269|PubMed:21035104, ECO:0000269|PubMed:21712028, ECO:0000269|PubMed:23108490, ECO:0000269|PubMed:23471613}. Note=The disease is caused by variants affecting the gene represented in this entry.

Similarity: Belongs to the opioid neuropeptide precursor family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.



Function:		Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.



Function:		Leumorphin has a typical opiod activity and may have anti- apoptotic effect. {ECO:0000250}.


Subcellular location:		Secreted.
Ptm:		The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Disease:		Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269\|PubMed:21035104, ECO:0000269\|PubMed:21712028, ECO:0000269\|PubMed:23108490, ECO:0000269\|PubMed:23471613}. Note=The disease is caused by variants affecting the gene represented in this entry.
Similarity:		Belongs to the opioid neuropeptide precursor family. {ECO:0000305}.