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UniProt functional annotation for Q9NII7 | ||
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| UniProt code: Q9NII7. |
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| Organism: | |
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. |
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| Function: | |
Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR. {ECO:0000269|PubMed:20713119, ECO:0000269|PubMed:9354615}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:20713119}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:20713119}. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). |
| Mass spectrometry: | |
Mass=3960.88; Method=MALDI; Evidence={ECO:0000269|PubMed:20713119}; |
| Toxic dose: | |
LD(50) is 2.0 ug/kg by intracerebroventricular injection into mice. {ECO:0000269|PubMed:9354615}. |
| Miscellaneous: | |
Has no effect on rat Kv1.4/KCNA4, Kv1.5/KCNA5, Kv4.1/KCND1 or human Kv11.1/KCNH2 and Kv3.1/KCNC1 (PubMed:20713119). Has no effect on bovine KCa1.1 (PubMed:9354615). {ECO:0000269|PubMed:20713119, ECO:0000269|PubMed:9354615}. |
| Miscellaneous: | |
The primary structure of this mature peptide is identical to that of toxin alpha-KTx 3.19 from Mesobuthus eupeus (AC C0HJQ6). {ECO:0000305}. |
| Similarity: | |
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 03 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.