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UniProt functional annotation for C3VPR6 | ||
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| UniProt code: C3VPR6. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|PubMed:20434986}. |
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| Subunit: | |
Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Tissue specificity: | |
Expressed in spleen, thymus and lung. {ECO:0000269|PubMed:20434986}. |
| Induction: | |
By interferon gamma. By LPS and viruses (at protein level). {ECO:0000269|PubMed:20434986}. |
| Miscellaneous: | |
[Isoform 2]: Due to intron retention. {ECO:0000305}. |
| Similarity: | |
Belongs to the NLRP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.