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UniProt functional annotation for P26349 | ||
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| UniProt code: P26349. |
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| Organism: | |
Heloderma suspectum (Gila monster). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma. |
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| Function: | |
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. {ECO:0000269|PubMed:19837656, ECO:0000269|PubMed:8405712}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Mass spectrometry: | |
Mass=4186.02; Method=MALDI; Evidence={ECO:0000269|PubMed:16386282}; |
| Pharmaceutical: | |
Available under the name Byetta and Bydureon (extended- release exenatide) (Amylin Pharmaceuticals). Used for the treatment of type 2 diabetes. Enhances insulin secretion in response to elevated plasma glucose levels. |
| Similarity: | |
Belongs to the glucagon family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.