|
|
||
|
|
|
|
|
UniProt functional annotation for Q2FWI8 | ||
|
|
|
|
|
|
||
| UniProt code: Q2FWI8. |
|
||
| Organism: | |
Staphylococcus aureus (strain NCTC 8325 / PS 47). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
|
||
|
||
| Function: | |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single- stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. {ECO:0000250|UniProtKB:A6QIR4}. |
|
||
| Subunit: | |
Forms a complex with MazE which is no longer active as an endoribonuclease. {ECO:0000250|UniProtKB:A6QIR4}. |
| Similarity: | |
Belongs to the PemK/MazF family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.