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UniProt functional annotation for Q9H5X1 | ||
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| UniProt code: Q9H5X1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227). {ECO:0000250, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:25716227}. |
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| Subunit: | |
Monomer and homodimer (PubMed:22683786). Component of the CIA complex (PubMed:23891004). Interacts with CIAO1 (PubMed:23891004, PubMed:22683786). Interacts with IREB2 (PubMed:23891004). Interacts with APAF1 (PubMed:25716227). {ECO:0000269|PubMed:22683786, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:25716227}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:22683786}. |
| Tissue specificity: | |
Substantially enriched in macrophages. {ECO:0000269|PubMed:22683786}. |
| Similarity: | |
Belongs to the MIP18 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.