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UniProt functional annotation for P55957 | ||
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| UniProt code: P55957. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}. |
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| Subunit: | |
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH (PubMed:20392206). Interacts with PLEKHN1 (PubMed:29531808). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:29531808}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14583606}. Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}. |
| Subcellular location: | |
[BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250|UniProtKB:P70444}. |
| Subcellular location: | |
[BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Associated with the mitochondrial membrane. {ECO:0000250|UniProtKB:P70444}. |
| Subcellular location: | |
[Isoform 1]: Cytoplasm {ECO:0000269|PubMed:14583606}. |
| Subcellular location: | |
[Isoform 3]: Cytoplasm {ECO:0000269|PubMed:14583606}. |
| Subcellular location: | |
[Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269|PubMed:14583606}. |
| Tissue specificity: | |
Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). {ECO:0000269|PubMed:14583606}. |
| Domain: | |
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti- apoptotic members of the Bcl-2 family. |
| Ptm: | |
TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products. {ECO:0000250|UniProtKB:P70444}. |
| Ptm: | |
p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. {ECO:0000269|PubMed:20392206}. |
| Sequence caution: | |
Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.