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UniProt functional annotation for A4ITV2 | ||
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| UniProt code: A4ITV2. |
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| Organism: | |
Geobacillus thermodenitrificans (strain NG80-2). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. |
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| Function: | |
Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. May monitor cellular heme or NO levels. {ECO:0000250|UniProtKB:P37484}. |
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| Catalytic activity: | |
Reaction=3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')- adenosine + H(+); Xref=Rhea:RHEA:54420, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71500, ChEBI:CHEBI:138171; EC=3.1.4.59; Evidence={ECO:0000250|UniProtKB:P37484}; |
| Cofactor: | |
Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000269|PubMed:21257773, ECO:0000305|PubMed:23504327}; Note=Binds 1 heme b per subunit. {ECO:0000269|PubMed:21257773}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P37484}; Note=Probably binds 2 Mn(2+) per subunit. {ECO:0000250|UniProtKB:P37484}; |
| Subunit: | |
The PAS-like domain (residues 55-162) dimerizes. {ECO:0000269|PubMed:23504327}. |
| Subcellular location: | |
Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. |
| Domain: | |
Binds heme b via the PAS-like domain. {ECO:0000269|PubMed:21257773}. |
| Similarity: | |
Belongs to the GdpP/PdeA phosphodiesterase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.