|
|
||
|
|
|
|
|
UniProt functional annotation for P9WJS9 | ||
|
|
|
|
|
|
||
| UniProt code: P9WJS9. |
|
||
| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
|
||
|
||
| Function: | |
Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. {ECO:0000269|PubMed:23431276}. |
|
||
| Subunit: | |
Interacts with MmpL4. Can also interact with MmpL5. {ECO:0000269|PubMed:23431276}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000269|PubMed:23431276}; Single-pass membrane protein {ECO:0000255}. |
| Induction: | |
Transcriptionally regulated by MmpR5 (PubMed:24737322). Repressed by iron and IdeR (PubMed:12065475). {ECO:0000269|PubMed:12065475, ECO:0000269|PubMed:24737322}. |
| Disruption phenotype: | |
Deletion mutant does not exhibit a low iron growth phenotype, but has attenuated virulence compared to the wild- type strain. Deletion of both mmpS4 and mmpS5 drastically decreases synthesis and secretion of siderophores, and greatly reduces virulence in mice. {ECO:0000269|PubMed:23431276}. |
| Similarity: | |
Belongs to the MmpS family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAC26395.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.