UniProt functional annotation for Q06263



	UniProt functional annotation for Q06263

UniProt code: Q06263.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:14701806, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096}.

Subunit: Homodimer (in cytoplasm). Interacts with VPS4; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex; the interaction is ADP- dependent. Interacts with SNF7; the interaction requires DID2. Interacts with DID2. Interacts with VPS60; the interaction occurs at he endosomal membrane. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:14701806, ECO:0000269|PubMed:15086794, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096, ECO:0000269|PubMed:18032584, ECO:0000269|PubMed:18194651, ECO:0000269|PubMed:18194652, ECO:0000269|PubMed:18280501}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:14701806}. Endosome membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14701806}.

Miscellaneous: Present with 4400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the VTA1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold. {ECO:0000269\|PubMed:12953057, ECO:0000269\|PubMed:14701806, ECO:0000269\|PubMed:16505166, ECO:0000269\|PubMed:16601096}.


Subunit:		Homodimer (in cytoplasm). Interacts with VPS4; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex; the interaction is ADP- dependent. Interacts with SNF7; the interaction requires DID2. Interacts with DID2. Interacts with VPS60; the interaction occurs at he endosomal membrane. {ECO:0000269\|PubMed:12953057, ECO:0000269\|PubMed:14701806, ECO:0000269\|PubMed:15086794, ECO:0000269\|PubMed:16505166, ECO:0000269\|PubMed:16601096, ECO:0000269\|PubMed:18032584, ECO:0000269\|PubMed:18194651, ECO:0000269\|PubMed:18194652, ECO:0000269\|PubMed:18280501}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:14701806}. Endosome membrane {ECO:0000269\|PubMed:14562095}; Peripheral membrane protein {ECO:0000269\|PubMed:14701806}.
Miscellaneous:		Present with 4400 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the VTA1 family. {ECO:0000305}.