|
|
||
|
|
|
|
|
UniProt functional annotation for P50534 | ||
|
|
|
|
|
|
||
| UniProt code: P50534. |
|
||
| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
|
||
|
||
| Function: | |
The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. {ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:7588059, ECO:0000269|PubMed:7781064, ECO:0000269|PubMed:7796814}. |
|
||
| Subunit: | |
Component of the male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3. {ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:7588059, ECO:0000269|PubMed:7781064, ECO:0000269|PubMed:7796814}. |
| Subcellular location: | |
Nucleus. Chromosome. Note=Msl-1 and msl-2 colocalize to many sites on the male X chromosome. |
| Developmental stage: | |
Only produced in males. |
| Similarity: | |
Belongs to the MSL2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.