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UniProt functional annotation for Q38503 | ||
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| UniProt code: Q38503. |
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| Organism: | |
Bacillus phage phi29 (Bacteriophage phi-29). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Picovirinae; Salasvirus. |
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| Function: | |
Inhibits the host uracil-DNA glycosylase (UDG), an enzyme which removes uracil residues from DNA by the base excision repair. Interacts with host uracil-DNA glycosylase and prevents the latter from binding to DNA. Since the viral DNA polymerase efficiently incorporates dUMP into DNA, the virus needs to prevent the deleterious effect caused by host UDG when it eliminates uracil residues present in the viral genome. {ECO:0000269|PubMed:17698500, ECO:0000269|PubMed:18845683, ECO:0000269|PubMed:21542855}. |
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| Subunit: | |
Homodimer (PubMed:17698500, PubMed:21890898). Interacts with host UDG; this interaction inhibits the uracil-DNA glycosylase (PubMed:17698500). {ECO:0000269|PubMed:17698500, ECO:0000269|PubMed:21890898}. |
| Similarity: | |
Belongs to the phi29likevirus protein p56 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.